Novantrone for
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Novantrone for treating Multiple Sclerosis (MS)

Novantrone is used to reduce relapses and disability in patients with the following forms of MS:

• secondary (chronic) progressive
• progressive relapsing
• worsening relapsing-remitting

Novantrone is not for patients with primary progressive MS.

Novantrone can cause the following serious problems:

• Novantrone may damage your heart at any time during treatment or months to years after treatment ends. Heart damage from Novantrone can be serious and may cause death. Your chance of heart problems depends on the amount of Novantrone you have used. Your doctor will limit your number of Novantrone doses. Your doctor will do certain tests to see if your heart is normal:
  • before you start Novantrone
  • before each dose of Novantrone
• if you have symptoms of heart problems during and after treatment with Novantrone
• Novantrone can increase your chance of getting an infection.
• Patients treated with Novantrone have an increased chance of developing leukemia.

Novantrone should not be used:

• by women who are pregnant or trying to get pregnant
• if your heart's ability to pump blood is decreased
• if you have a low number of white blood cells
• if you are allergic to Novantrone

Before taking Novantrone, tell your doctor about your past and current health conditions including:

• heart disease
• cancer treatment
• radiation to the chest
• blood-clotting or bleeding problems
• low blood counts
• infections
• liver disease or problems

Tell your doctor about all the medicines you take. Tell your doctor if you ever had treatment with Novantrone.

The most common side effects of Novantrone in patients with MS are nausea, hair thinning, loss of menstrual periods, mouth sores, and bladder infections.

For more information, read the Novantrone Patient Information leaflet. Talk to your doctor about questions or concerns with Novantrone treatment.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

This information is intended only for residents of the United States.

©2007 EMD Serono, Inc. All rights reserved